Ketogenic diets show promise with Neurological diseases..

We have known for decades the positive effects of ketogenic diets upon epilepsy and other seizure disorders. Slowly we are beginning to correlate inflammatory conditions and immune dysfunction with ASD and other neurological disease risks in children.

So how does this work?

Ketogenic diets in essence restrict glycolysis and increases fatty acid oxidation forcing the neurological cells to rely upon the resulting ketone bodies for energy vs. glucose.

These ketone bodies seem to enhance cellular metabolism and improve mitochondrial function. This alternative energy pathway contributes to a cascade effect of much needed processes lacking in those with neuroinflammatory and mitochondrial diseases such as autism spectrum disorder, Alzheimer's disease, Parkinson's disease, epilepsy and ALS.

It is thought that Ketone bodies via increased cellular signaling assist with restoration of neurotransmitter and ion channel functions. Ketone bodies also change metabolism and neuronal excitability thought to increase ATP. Increasing ATP ultimately raises adenosine levels in the brain and restores DNA methylation. Ketone bodies also influence regulatory effects upon glutamate by blunting it's release.

Research shows that adenosine plays a major role in cognition often a symptom of neurological conditions and glutamate in high doses can contribute to agitation, social anxieties, insomnia, severe mood swings, mania and addictive behaviors.

The ketone bodies generated from the diet seem to alter the brains processing of glutamate, an excitatory neurotransmitter. Through a complex process it seems as if ketones trigger more production of GABA which assists with a glutamate purge.  The benefit is less provocation by an excitatory neurotransmitter.

Adenosine can translate ketone provoked metabolic changes into enhanced energy metabolism of the brain.

Anecdotally as a practice, we find positive changes with cognition and sociability with our autism spectrum disorder population and less inflammatory symptoms in our chronic tick-borne illnesses and autoimmune disease patients.

If you would like to learn more about what the ketogenic diet can do for you, visit Dr. Kenneth Bock or his colleague Somer DelSignore to discuss further!

 

 

What's in an orange peel?

A supplement used for many years by French women to repair varicose veins seems to have many health benefits. Hesperidin and diosmin a synergistic combination of flavonoids found in orange peel shows promise with improved microcirculation, lymphatic drainage , antioxidant and tissue healing properties.

Several studies show numerous beneficial effects upon the gastrointestinal , vascular and neurological system by increasing blood flow to the areas and blocking prostaglandins. This supplement seems to have positive effects upon microcirculation in the body. Also, Superoxide dismutase, a powerful antioxidant, was elevated with the use of diosmin and hesperidin providing free radical protection.

Other studies show promise with neurodegenerative diseases. It seems that hesperidin ameliorates MPTH (1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine) induced motor dysfunction and also significantly protects microglia activation reductase release of inflammatory cytokines. It is thought that neuroinflammation contributes to neurodegenerative diseases and the use of this flavonoid combination seems to have a  positive impact.

Another beneficial use currently under investigation is diosmin and hesperidin's effects upon depression and anxiety. Some studies show increased signaling of serotonin with it's use but needs further investigation.

We'll continue to trend this supplement and it's potential uses within our patient population. Food for thought!

 

Tick Tips

It's that time of year again! The beautiful weather brings out those pesky ticks and with it tick bites! Each year the CDC reports upwards of 300,000+ people exposed to Lyme disease and other tick borne infections. No need to hide inside this season. We've provided some recommendations to keep those ticks and other critters at bay this Summer.

1. Cover up Vulnerable Areas- Long pants tucked into socks, a fashionable look for some, can prevent ticks from latching on. Also wearing quick dry clothing may deter ticks from further seeking a comfy spot to attach. They need moisture to survive.

2. Repel, Repel, Repel! - use permethrin on clothing, socks and shoes avoiding direct skin contact. Evidence suggests using DEET is ineffective. Also use a natural insect repellent for your skin and hair. I personally use Bug Away by Three Sisters Herbals on my entire family to include the dog.  There are many safe herbal options in your local health food stores and apothecaries.

3. Be Mindful at Home- The majority of lyme exposures are reported around the home. Understand that outdoor adventures also pose a threat but are not the most common. Always consider an exposure risk while out and about on your lawn.

4. Tick Checks!- Always.....let me repeat..ALWAYS perform daily tick checks of yourself, your family and pets. Make this a habit anytime you are out enjoying nature.

5. Lower those Carbs! Ticks seek out carbon dioxide when searching for prey. The more carbohydrates we eat, the more carbon dioxide we breath off therefore attracting the attention of ticks. This goes for mosquitoes too!

6. Soak up the Sun- a tick's anatomy prevents long term survival in low humidity. This is why we find them often in shady, brush covered areas. Stay in the sun!

7. Evaluate your Lawn- deer and small rodents, particularly mice avoid certain plants and herbs. Try planting things like Mint, thyme, lavender, black-eyed susan, lemon balm, Mexican marigold and chrysanthemum around the perimeter of your lawn to keep deer and most small rodents out preventing ticks from hitching a ride. Coincidentally, mosquitoes, deer flies and black flies will stay away from most of these plants as well. Ticks will not cross a woodchip barrier. Creating these around the edge of your lawn  will keep them away. Clean up brush and keep grass on the shorter side.  These changes to your lawn can create an unsuitable environment for ticks to thrive ultimately providing you and your family some protection without the use of toxic chemical sprays.

If you do by chance find a tick attached remove it immediately and seek out the advice of your lyme-literate provider!

Enjoy your Summer season and remain vigilant!

 

 

Detoxification in Childhood Neuroimmune Disorders

Detoxification in Childhood Neuroimmune Disorders

Detoxification requires a good deal of energy. Unfortunately, the accumulation of toxins can damage the mitochondria that provide that energy for our cells, and this can initiate a downward cycle, so many individuals need assistance to support detoxification.