Olive leaf extract and its extraordinary properties!

Olive Leaf Extract is highly regarded throughout history for its rejuvenating and healing properties. Ancient Egyptians used it regularly for its many medicinal properties. Biblical references note olive leaf perhaps to be the" tree of life". Fast-forward to the late 1800’s and beyond, shows its use against malaria and febrile illnesses along with an article in Pharmaceutical Journal suggesting a recipe for olive leaf tinctures and directions for use against fevers. Decades later, Scientists across Britain, Denmark, Italy and the United States were able to isolate the active ingredient, oleuropein from the olive leaf. Oleuropein was trialed and found to be effective against hypertension, reducing blood sugar, improving clotting and vascular issues and more recently as a potent antiviral, antibacterial and antifungal herbal. American researchers in the 1960s reported oleuropein to impact every virus tested against it.  It seems as though oleuropein dissolves the outer lining of microbes killing them. Also of note is its effectiveness against some cancers. Animal model studies show oleuropein’s ability to inhibit growth factors and disrupt signaling pathways for cancer cells. Further research needs to occur with human model studies to make any further claims.

As a lyme specialist, I love this stuff! I use oleuropein often to support the immune system, treat viral illnesses and those suffering from candida overgrowth and SIBO (another topic for another day).  The spirochete known to cause lyme disease produces a toxic outer surface protein Osp A. This protein suppresses the immune system by dampening its ability to proliferate lymphocytes.  It also suppresses B cells and antibody producing plasma cells. This can explain the lack of antibodies produced in presence of an active lyme infection.  Those of you with lyme disease and “negative” lyme laboratory results, hopefully this sheds some light.

The take away here is a suppressed immune system can give rise to re-activation of dormant viruses and other opportunist infections, making treatment even more challenging! 

 Chiao JW, Villalon P, Schwartz I, Wormser GP. FEMS. Immunol Med.Microbiol; 2000 July; 28(3): 193-6.    Elsner RA, Hastey CJ, Olsen KJ, Baumgarth N. PLoS Pathog; 2015 Jul; 11(7):e1004976.

As a general immune support supplement, it’s worth its weight in gold! Perhaps something to consider during those winter virus months. Contact our office for further details!

Stay healthy Bock patient family!

Somer DelSignore, PCCNP, BC-PNP

Lyme Specialist


  1. Montilla MP, Agil A, Navarro MC, Jimenez MI, Garcia-Granados A, Parra A et al. Antioxidant activity of maslinic acid, a triterpene derivative obtained from Olea europaea. Planta Med 2003;69:472-4.
  2. Gonzalez M, Zarzuelo A, Gamez MJ, Utrilla MP, Jimenez J, Osuna I. Hypoglycemic activity of olive leaf. Planta Med 1992;58:513-5.
  3. Markin D, Duek L, Berdicevsky I. In vitro antimicrobial activity of olive leaves. Mycoses 2003;46:132-6.
  4. Lee-Huang S, Zhang L, Huang PL, Chang YT, Huang PL. Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment. Biochem.Biophys.Res Commun. 2003;307:1029-37.
  5. PDR for Herbal Medicines. Montvale, NJ: Medical Economics, 1998.
  6. Somova LI, Shode FO, Ramnanan P, Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. Journal of Ethnopharmacology.Vol.84(2-3)()(pp 299-305), 2003. 2003;299-305.
  7. Pasquale RD, Monforte A, Trozzi A, Raccuia S, Tommasini S, Ragusa S. Effects of leaves and shoot of Olea europaea L. and oleuropien on experimental hypercholesterolemia in rat. Plantes Med Phytother 1991;25:134-40.
  8. Horn C. Olive leaf to fight infection. Natural Health 2000;30:40.
  9. Zarzuelo A, Duarte J, Jimenez J, Gonzalez M, Utrilla MP. Vasodilator effect of olive leaf. Planta Med 1991;57:417-9.
  10. Pieroni A, Heimler D, Pieters L, van Poel B, Vlietinck AJ. In vitro anti-complementary activity of flavonoids from olive (Olea europaea L.) leaves. Pharmazie 1996;51:765-8.
  11. Brinker F. Herb Contraindications And Drug Interactions. Sandy, OR: Eclectic Medical Publications, 2001.
  12. Liccardi G, D’Amato M, D’Amato G. Oleaceae pollinosis: a review. Int Arch.Allergy Immunol. 1996;111:210-7.
  13. Kimura Y, Sumiyoshi M. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. J Nutr. 2009 Nov;139(11):2079-86.
  14. Anter J, Fernández-Bedmar Z, Villatoro-Pulido M, et al. A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts. Mutat Res. 2011 May 20. [Epub ahead of print].
  15. Mijatovic SA, Timotijevic GS, Miljkovic DM, et al. Multiple antimelanoma potential of dry olive leaf extract. Int J Cancer. 2011 Apr 15;128(8):1955-65.
  16. Perrinjaquet-Moccetti T, Busjahn A, Schmidlin C, et al. Food supplementation with an olive (Olea europaea L.) leaf extract reduces blood pressure in borderline hypertensive monozygotic twins. Phytother Res. 2008 Sep;22(9):1239-42.
  17. Susalit E, Agus N, Effendi I, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytomedicine. 2011 Feb 15;18(4):251-8.
  18. Abaza L, Talorete TP, Yamada P, et al. Induction of growth inhibition and differentiation of human leukemia HL-60 cells by a Tunisian gerboui olive leaf extract. Biosci Biotechnol Biochem. 2007 May;71(5):1306-12.
  19. Anter J, Fernández-Bedmar Z, Villatoro-Pulido M, et a. A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts. Mutat Res. 2011 Aug 16;723(2):165-70.
  20. Kaeidi A, Esmaeili-Mahani S, Sheibani V, et al. Olive (Olea europaea L.) leaf extract attenuates early diabetic neuropathic pain through prevention of high glucose-induced apoptosis: in vitro and in vivo studies. J Ethnopharmacol. 2011 Jun 14;136(1):188-96.
  21. Esmaeili-Mahani S, Rezaeezadeh-Roukerd M, Esmaeilpour K, et al. Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats. J Ethnopharmacol. 2010 Oct 28;132(1):200-5.
  22. Pereira AP, Ferreira IC, Marcelino F, et al. Phenolic compounds and antimicrobial activity of olive (Olea europaea L. Cv. Cobrançosa) leaves. Molecules. 2007 May 26;12(5):1153-62