A supplement used for many years by French women to repair varicose veins seems to have many health benefits. Hesperidin and diosmin a synergistic combination of flavonoids found in orange peel shows promise with improved microcirculation, lymphatic drainage , antioxidant and tissue healing properties.
Several studies show numerous beneficial effects upon the gastrointestinal , vascular and neurological system by increasing blood flow to the areas and blocking prostaglandins. This supplement seems to have positive effects upon microcirculation in the body. Also, Superoxide dismutase, a powerful antioxidant, was elevated with the use of diosmin and hesperidin providing free radical protection.
Other studies show promise with neurodegenerative diseases. It seems that hesperidin ameliorates MPTH (1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine) induced motor dysfunction and also significantly protects microglia activation reductase release of inflammatory cytokines. It is thought that neuroinflammation contributes to neurodegenerative diseases and the use of this flavonoid combination seems to have a positive impact.
Another beneficial use currently under investigation is diosmin and hesperidin's effects upon depression and anxiety. Some studies show increased signaling of serotonin with it's use but needs further investigation.
We'll continue to trend this supplement and it's potential uses within our patient population. Food for thought!